N Hydroxysuccinimide

N Hydroxysuccinimide Specification

Usage
Used as a reagent in peptide synthesis to activate carboxylic acids for amide bond formation. Involved in the preparation of NHS esters for protein labeling and modification. Utilized in the carbodiimide method for improved amidations and peptide couplings. Applied in biosensor development for enzyme immobilization

Properties
Physical Form Crystalline solid Product Type Organic Intermediate CAS No 6066-82-6 Molecular Formula C H NO Molecular Weight 115.09 g/mol EINECS No 228-001-3 HS Code 2921.19.00 Grade 98% (high purity) Purity 98% Appearance White to off-white crystalline powder Shape Crystalline Taste Not specified Smell Odorless Poisonous Yes, classified as harmful and hygroscopic

Solubility
Soluble in water, methanol, dimethylformamide, alcohols, and ethyl acetate; insoluble in cold ether

Payment Terms
Paypal, Cash Against Delivery (CAD), Cash on Delivery (COD), Cash Advance (CA), Cash in Advance (CID), Cheque, Days after Acceptance (DA), Delivery Point (DP), Letter of Credit at Sight (Sight L/C), Telegraphic Transfer (T/T), Western Union, Letter of Credit (L/C)

Main Export Market(s)
Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa

Main Domestic Market
Haryana, Himachal Pradesh, Madhya Pradesh, Maharashtra, All India, South India, Central India, Delhi, Arunachal Pradesh, Chhattisgarh, Tamil Nadu, Telangana, Tripura, Pondicherry, Uttar Pradesh, Uttarakhand, West Bengal, West India, North India, East India, Gujarat, Karnataka, Kerala, Andhra Pradesh, Bihar, Chandigarh, Jharkhand, Punjab, Assam

Certifications
Physical Form Crystalline solid Product Type Organic Intermediate CAS No 6066-82-6 Molecular Formula C H NO Molecular Weight 115.09 g/mol EINECS No 228-001-3 HS Code 2921.19.00 Grade 98% (high purity) Purity 98% Appearance White to off-white crystalline powder Shape Crystalline Taste Not specified Smell Odorless Poisonous Yes, classified as harmful and hygroscopic

Peptide Synthesis: NHS is widely used in peptide synthesis to activate carboxylic acids for coupling reactions. It reacts with carboxylic acids in the presence of coupling reagents (like DCC or EDC) to form N-hydroxysuccinimide esters, which are highly reactive intermediates. These esters readily react with amines to form amide bonds, the backbone of peptides.
Bioconjugation: NHS esters are also used to conjugate proteins, peptides, and other biomolecules to various carriers, such as:
- Fluorescent dyes: For labeling and tracking biomolecules.
- Enzymes: For immobilization and biocatalysis.
- Polymers: For creating biomaterials and drug delivery systems.